With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
4-[(4-methyl-1-piperidinyl) methyl] -3- (trifluoromethyl) -benzeneamine (360 mg, 1.33 mmol),N, N-Diisopropylethylamine (273 muL, 1.60 mmol),Dissolve DMAP (1.2 mg, 0.01 mmol) in THF (5.0 mL),3,5-Dibromo-4-methyl- benzoyl chloride (500 mg, 1.6 mmol) was added and stirred at room temperature for 2 hours.Add water and extract with ethyl acetate,It concentrated under reduced pressure with an evaporator.Silica gel column chromatography of the obtained residueThe compound 3 was purified by (chloroform: methanol = 10: 1).(540.0 mg, 0.98 mmol, 73.8%, pale yellow solid) were obtained., 694499-26-8
The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Kyoto University; Arkray Corporation; Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Nakanishi, Shuichi; (27 pag.)JP2019/64986; (2019); A;,
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