5464-12-0, 1-(2-Hydroxyethyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5464-12-0
To a 25 mL round bottom flask equipped with a stir bar was added 2-(4-methyl-piperazin-1-yl)-ethanol (0.079 mL, 0.65 mmol) and DMF (5 mL) and the solution was cooled to 0° C. in an ice-water bath after which sodium hydride (0.026 g, 0.65 mmol, 60percent oil dispersion) was added. The solution was allowed to stir at 0° C. for 20 minutes after which 2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]-amide (0.050 g, 0.093 mmol) (from Example 75 supra) was added all at once. The reaction was allowed to warm to room temperature and stir for 16 hours. The reaction was filtered and then purified by reverse-phase HPLC (Gilson, C-18 Polaris column; eluting with 30-100percent acetonitrile/water with 0.1percent TFA) to provide, after basification to remove the TFA, 2-[2-(4-methyl-piperazin-1-yl)-ethoxy]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]amide. (Yield 0.010 g, 18percent). LR-MS: [M+H]+: 610.
As the paragraph descriping shows that 5464-12-0 is playing an increasingly important role.
Reference：
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics