With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
General procedure: To a mixture of piperazine derivative (1.1 equiv) and benzimidazole-carboxylic acid derivative (1 equiv) in DMF (1 mL), (benzotriazol-1 -yloxy)tris(dimethylamino)phosphoniumhexafluorophosphate (BOP) (0.24 g, 0.55 mmol, 1 .3 equiv) and diisopropylethylamine(0.22 mL, 1.26 mmol, 3 equiv) were added. The reaction mixture was stirred at roomtemperature for 1 6h then NaCisat was added. The aqueous phase was extracted with ethylacetate (3x), then the combined organic phases were washed with 5percent NaHCO3 andNaCIsat, dried over MgSO4 and concentrated. The crude product was purified by columnchromatography (PE/EtOAc or CH2CI2/MeOH) to obtain the desired product, 31166-44-6
As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference：
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D’ORLEANS; AGROFOGLIO, Luigi; ROY, Vincent; PLEBANEK, Elzbieta; BESSIERES, Maxime; (105 pag.)WO2018/50771; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics