With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.
Dissolve 2, 3-DICHLOROPYRIDINE (8. 5 g, 0. 057 moles) and (R)- (-)-2-METHYLPIPERAZINE (5. 75 g, 0. 057 moles) in DMA (125. 0 mL) under nitrogen atmosphere. Add anhydrous powdered K2C03 (23. 75 g, 0. 172 moles) to this mixture and stir at 135-140°C for 48 hours. Cool the reaction mixture to room temperature, dilute with water (400 mL), extract with EtOAc (3 x 200 mL) and wash the combined organic extract with brine (2 x 150 mL). Dry over MgS04, concentrate under vacuum to afford crude product as orange yellow liquid. Distil the crude under high vacuum to afford pyridylpiperazine derivative as yellow viscous oil.
75336-86-6, The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
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