With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.,59702-31-7
1- (4-bromobutyl) -5-benzyloxy-2- (4-benzyloxy-phenyl) -3-methyl -1H- indole (1.0g, 1.8mmol), 1- ethyl piperazine-2,3-dione (0.5g, 3.6mmol), triethylamine (0.4g, 3.6mmol) placed in 100mL eggplant flask, n-butanol as solvent, the reaction was refluxed for 4h. Rotary evaporation. The residue was mixed with ethyl acetate and dissolved in ethanol, was added 10% Pd / C (0.2g, 0.4mmol), 45 reaction 24h. Filtered off Pd / C, the filtrate by rotary evaporation, column chromatography, as a white oil 0.22g, yield 49.1%
The synthetic route of 59702-31-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Shenyang Pharmaceutical University; Hu, Chun; Liu, Xiaoping; Zuo, Li; Huang, Erfang; Zhang, Lan; Jin, Zhe; (11 pag.)CN105801564; (2016); A;,
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