5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5308-25-8, A mixture of 4-amino-2-trifluoromethyl -benzoic acid (15 g, 73.1 mmol), HOBT (14.56 g, 95 mmol), EDC (16.82 g, 88 mmol), Et3N (20.38 mL, 146 mmol), 1-ethyl-piperazine (8.35 g, 73.1 mmol) in DCM (200 mL) was stirred at 25 C for 2 h. To the mixture was added DCM (200 mL) and then washed with H20, 2 M NaOH (2 x 150 mL) and brine. The organic layer was dried over NaaSOzi, filtered, and concentrated to give a off white solid of (4-amino-2-trifluoromethyl-phenyl)- (4-ethyl-piperazin-l-yl)-methanone (20 g, 65.2 mmol, 89.0% yield): NMR (400 MHz, CDC13) delta: 7.07 (d, J = 8.0 Hz, 1H), 6.92 (d, J = 2.4 Hz, 1H), 6.79 (dd, J = 2.0, 8.0 Hz, 1H), 3.99 (s, 2H), 3.84-3.76 (m, 2H), 3.25-3.23 (m, 2H), 2.50-2.39 (m, 4H), 2.33-2.31 (m, 2H), 1.08 (t, J = 7.2 Hz, 3H); ES-LCMS m/z 302 (M+H).
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; EIDAM, Hilary Schenck; DEMARTINO, Michael P.; GONG, Zhen; GUAN, Amy Huiping; RAHA, Kaushik; WU, Chengde; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; CHEUNG, Mui; WO2014/141187; (2014); A1;,
Piperazine – Wikipedia
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