With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
A solution of NaOEt was prepared from NaH (60% dispersion in mineral oil) (0.723 g, 19 mmol) and 20 mL EtOH. To this solution was added diethyl carbonate (8.50 mL, 70 mmol) and the mixture was transferred to a solution of (R)-4-N-BOC-2-hydroxymethyl-piperazine (1.523 g, 7.0 mmol) in 80 mL of EtOH and heated at 78 C. After 6.5 h the reaction was cooled to RT and filtered. The filtrate was concentrated to dryness to give an off-white amorphous solid.
278788-66-2, The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Amgen Inc.; US2006/199817; (2006); A1;,
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