With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
4-fluoro-3-nitrobenzenesulfonamide (235 mg, 1.06 mmol, 1.00 eq) and2 – ((1H-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4- (4 – ((4′-chloro-5,5-dimethyl- , 6-tetrahydro- [1,1′-biphenyl] -2-yl) methyl) piperazin-1-yl) benzoic acid(600 mg, 1.06 mmol, 1.0 eq) (see Example 1, Step 14) was added to 6 mL of phosphorus oxychloride and reacted at 85 C for 5 h. The reaction solution was poured into 20 mL of ice water and extracted with EA (10 mL x 3). The organic phase was separated, dried over anhydrous sodium sulfate, dried over the column, PE / EA (v / v) = 2/1 and DCM / EtOH (v / v) = 10/1 as an eluent to give 830 mg of a white solid product in 100% yield.
1235865-77-6, As the paragraph descriping shows that 1235865-77-6 is playing an increasingly important role.
Reference：
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
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