The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents, the main research direction is alkoxymethanesulfonamido acetophenone preparation ulcerogenic antiinflammatory.Synthetic Route of C9H7NO3.
A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. The synthesized compounds were also investigated for their gastric ulcerogenic potential. The compounds I (R = n-Bu, hexyl, and cyclohexyl) showed comparable anti-inflammatory activity to rofecoxib and indomethacin, the standard drugs taken in both studies and were also non ulcerogenic at the test doses. In silico (docking studies) were done to investigate the hypothetical binding mode of the target compounds to the cyclooxygenase isoenzyme (COX-2). A binding model has been proposed based on the docking studies. Selected physicochem. properties were calculated for theor. ADME profiling of the compounds and excellent compliance was shown with Lipinski’s rules.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics