The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The preparation of α-bromoacetals》. Authors are Marvell, Elliot N.; Joncich, Micheal J..The article about the compound:2-Bromopriopionaldehydediethylacetalcas:3400-55-3,SMILESS:CC(Br)C(OCC)OCC).Recommanded Product: 2-Bromopriopionaldehydediethylacetal. Through the article, more information about this compound (cas:3400-55-3) is conveyed.
Acetals can be brominated readily by N-bromosuccinimide (I). The predominant products from the di-Et acetals of AcH (II), EtCHO (III), PrCHO (IV), and iso-PrCHO (V) were the α-bromoacetals. A by-product containing a more reactive Br was noted in each case. PhCH(OEt)2 and I yielded EtOBz. I is better than Br for the preparation of α-bromoacetals. Me(CH2)5CHO and I yielded no pure product. I added to the acetal (equimolar quantities) in direct sunlight (temperature kept below 40°), the mixture cooled, filtered, washed with CCl4, the filtrate and washings shaken 30 min. with NaHCO3, the organic layer separated and distilled yielded the α-bromoacetal, of which the yield(%), b.p./mm., n20D, d2020, and MRD calculated (found) are: II, 57, 67°/15, 1.4401, 1.286, 40.9 (40.4); III, 68, 82-5°/30, 1.4371, 1.207, 45.6 (45.9); IV, 24, 74-7°/15, 1.4418, 1.170, 50.2 (50.9); V, 59, 87.5°/30, 1.4345, 1.141, 50.2 (50.6).
If you want to learn more about this compound(2-Bromopriopionaldehydediethylacetal)Recommanded Product: 2-Bromopriopionaldehydediethylacetal, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3400-55-3).
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics