Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Alkylbenzoxazolinones. Chemical and pharmacodynamic studies.Related Products of 54903-09-2.
Eleven title compounds (I; R1 = Me or H; R2 = Me, Ph, benzyl, CH2Cl, CH2Br, or CHBrM4) were prepared by a general method consisting of reduction of the corresponding 6-acyl derivatives (OCR2) with Et3SiH in F3CCO2H medium. Yields were 50-90%, with no side products. Six I were screened in mice for acute toxicity and for analgesic and psychotropic activities. At 200 mg/kg, orally, these compounds had lower analgesic activity than the reference substance, 6-benzoylbenzoxazolinone; at 100 mg/kg, only 6-ethylbenzoxazolinone [93771-18-7] was more active, but this analgesic activity was accompanied by a psychotropic component. Furthermore, this psychotropic activity was found with almost all the I at the dose of 200 mg/kg, a component which was not present in the previously studied carbonyl (6-acyl) analogs.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics