The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.Safety of (S)-Methyl 3-hydroxybutanoate.Ni, Hongliang; Yao, Shanjing published the article 《Biosynthesis of optically active methyl β-hydroxybutanoate by yeast cells》 about this compound( cas:53562-86-0 ) in Huaxue Fanying Gongcheng Yu Gongyi. Keywords: acetoacetate stereoselective reduction hydroxybutyrate yeast fermentation. Let’s learn more about this compound (cas:53562-86-0).
The Me β-hydroxybutanoate (MHB) with optically activity was synthesized by Me acetoacetate (MAA) over different yeasts in aqueous phase. Effects of reaction time, yeast concentration, glucose concentration, buffer pH, reaction temperature and substrate concentration on the yield and the stereoselectivity of (S)-MHB were investigated. The results showed that bakers’ yeast was effective catalyst. The optimal conditions were reaction time 4 h, bakers’ yeast 50 g/L, glucose 0.6 M, substrate MAA 0.05 M, pH 7, 35°. Me β-hydroxybutanoate yield and enantiomeric excess were 57% and 92%, resp.
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Reference:
Piperazine – Wikipedia,
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