So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ubale, Panchsheela; Mokale, Santosh; More, Shweta; Waghamare, Shailesh; More, Vikramsinh; Munirathinam, Nethaji; Dilipkumar, Suma; Das, Rajesh Kumar; Reja, Sahin; Helavi, Vasant B.; Kollur, Shiva Prasad researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Reference of 1,10-Phenanthroline.They published the article 《Evaluation of in vitro anticancer, antimicrobial and antioxidant activities of new Cu(II) complexes derived from 4(3H)-quinazolinone: Synthesis, crystal structure and molecular docking studies》 about this compound( cas:66-71-7 ) in Journal of Molecular Structure. Keywords: copper quinazolinone schiff base complex preparation crystal structure; mol docking copper quinazolinone schiff base complex; anticancer antimicrobial antioxidant activity copper quinazolinone schiff base complex. We’ll tell you more about this compound (cas:66-71-7).
Present study describes synthesis of a series of Cu(II) metal complexes (C1 – C3) of bidentate Schiff base ligands (L1 – L3) derived from the condensation reaction of 3-amino-2-methyl-4(3H)quinazolinone with 2-chlorobenzaldehyde, 4-bromobenzaldehyde and 2-nitrobenzaldehyde. The structural characterization of synthesized compounds was analyzed on the basis of FTIR, UV-Visible, 1H NMR and mass spectroscopy. The orthorhombic structure of the L3 is determined by x-ray crystallog. anal. In silico anal. of all compounds against various protein targets prove to have better interaction parameters in case of c-MET and VEGFR, thus in accordance with the docking score, the colon cell line (HT-29) was selected for further in vitro anal. and L3, C1, C2 and C3 exhibit important anticancer activity when compared with the standard drug Adriamycin. Further, synthesized compounds showed excellent activity against Gram-pos. (Staphylococcus aureus) and Gram-neg. pathogens (Escherichia coli) but exhibited poor activity against fungal strain. Antioxidant activity of the all compounds revealed that the complexes displayed a higher scavenging activity than the corresponding ligands. These studies reveal that the coordination of Cu(II) ion with mixed ligands play a vital role in the enhancement of the biol. potential of the complexes.
There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Reference of 1,10-Phenanthroline, and with the development of science, more effects of this compound(66-71-7) can be discovered.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics