Category: piperazines. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Synthesis and characterization of a high-purity chiral 5,5′-disulfonato-BINAP ligand and its application in asymmetric hydrogenation of β-keto esters.
An improved oleum sulfonation method for the synthesis of the high-purity 5,5′-disulfonato-(S)-BINAP ligand with an industrially acceptable high yield is reported. By optimizing the sulfonation conditions and improving the workup process, the yield of 5,5′-disulfonated products was enhanced to 73%. Furthermore, an acetonitrile extraction protocol was developed for the purification of sulfonated products by efficiently removing phosphine oxides, by which the content of phosphine oxide can be controlled below 3%. The prepared high-purity 5,5′-disulfonato-(S)-BINAP was evaluated in the Ru-catalyzed asym. hydrogenation of β-keto esters, which exhibited high catalytic activity, enantioselectivity and excellent catalytic stability. Thus,(S)-Me and (S)-Et 3-hydroxybutanoate were obtained.
There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CC(OC)=O)Category: piperazines, and with the development of science, more effects of this compound(53562-86-0) can be discovered.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics