Synthetic Route of C8H8FN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Palladium-Catalyzed Direct and Specific C-7 Acylation of Indolines with 1,2-Diketones. Author is Xie, Guilin; Zhao, Yuhan; Cai, Changqun; Deng, Guo-Jun; Gong, Hang.
Herein, a palladium-catalyzed direct and specific C-7 acylation of indolines in the presence of an easily removed directing group was developed. This strategy usually considered as a practical strategy for the preparation of acylated indoles because indoline can be easily converted to indole under oxidation conditions. In particular, these strategy greatly improved the alkacylation yield of indolines for which only an unsatisfactory yield could be achieved in the previous studies. Furthermore, the reaction can be scaled up to gram level in the standard reaction conditions with a much lower palladium loading (1 mol %).
There is still a lot of research devoted to this compound(SMILES：FC1=CC2=C(NCC2)C=C1)Synthetic Route of C8H8FN, and with the development of science, more effects of this compound(2343-22-8) can be discovered.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics