The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.SDS of cas: 53562-86-0.Raval, R.; Baddeley, C. J.; Haq, S.; Louafi, S.; Murray, P.; Muryn, C.; Lorenzo, M. Ortega; Williams, J. published the article 《Complexities and dynamics of the enantioselective active site in heterogeneous catalysis》 about this compound( cas:53562-86-0 ) in Studies in Surface Science and Catalysis. Keywords: copper catalyst surface modified chiral mol activity; hydrogenation ketoester enantioselective site catalyst mechanism; methylacetoacetate hydrogenation stereocontrol chiral catalyst site. Let’s learn more about this compound (cas:53562-86-0).
Stereocontrol mechanisms in chirally modified metals in heterogeneous catalysis for enantioselective reactions were studied. Effective systems were produced by first modifying a metal surface with chiral mols. and, subsequently, conducting the enantioselective reaction on the modified surface. The asym. hydrogenation of β-ketoesters (methylacetoacetate) over R,R-tartaric acid and S-alanine modified Cu(110) surfaces was used as model. The products are S and R-methyl-3-hydroxybutyrates. Surface spectroscopy methods were used to characterize modified surfaces created under ultra-clean and controlled environments; the adsorbed modifiers, R,R-tartaric acid and S-alanine, display rich and complex phase diagrams in which the chem. nature and 2-dimensional organization of the chiral units varies considerably as a function of surface coverage and temperature The models suggested for stereocontrol involving one-to-one interaction between the adsorbed chiral modifier and the reactant (substrate) are, perhaps, too simplistic and careful account needs to be taken of the complexities and dynamic interplay between different modifier phases at a surface to fully understand the nature and scope of stereocontrol.
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Reference:
Piperazine – Wikipedia,
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