Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 66-71-7, is researched, Molecular C12H8N2, about Design, Synthesis, Bioanalytical, Photophysical and Chemo-phototherapeutic Studies of Heteroleptic Cu(II) Complexes, the main research direction is copper complex thermodn property anticancer mol docking.Product Details of 66-71-7.
A broad investigation has been paid to design an alternative metal-based anticancer drug, bearing metal ions other than platinum, with more target specificity. In this regard, Cu(II) complexes showed a remarkable intercalation binding property with DNA which have received much attention in the development of efficient anticancer drugs. A series of mononuclear ternary Cu(II) complexes A, B and C were prepared with H2L and auxiliary ligand. The synthesized H2L and corresponding complexes were characterized using various electroanal. and physicochem. techniques. The thermodn. parameters were calculated using Gibb′s-Helmholtz, Arrhenius and Eyring equations. Morphol., binding energies of core electrons and crystallog. nature of the metal complexes were evaluated by SEM, XPS and PXRD techniques. Binding studies of the metal complexes with CT-DNA were conducted by absorption, fluorescence and viscometric methods. The pBR322 cleavage, antioxidant and mol. docking studies revealed the potent biol. activity of title complexes. In-vitro cytotoxicity of these biol. active biomaterials tested against HeLa and MCF-7 by MTT assay and DAPI staining revealed their anticancer activity. Such results are supportive for advanced studies which would come through insight for their possible applications.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics