Zhang, Ya-Wen; Shen, Zong-Xuan; Qin, Hong-Bing; Li, Yong-Hua; Yu, Kai-Bei published an article about the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2,SMILESS:C[C@H](O)CN(C)C ).Application of 53636-17-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53636-17-2) through the article.
Some α-(dialkylamino) ketones and β-(dialkyl amino) ketones were reduced stereoselectively by 2 mol of borane-tetrahydrofuran in the presence of 10 mol% of an in situ-formed chiral oxazaborolidine, followed by diluted hydrochloric acid. The catalysts in this study included (3aR)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, (3aS)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole and (4R,5S)-2-methyl-4,5-diphenyl-1,3,2-oxazaborolidine. The resulting amino alc.-borane complexes were treated with hydrogen chloride-glycol-methanol to give the optically active amino alc. with the ee up to 99%. For example, the reduction of 3-(4-morpholinyl)-1-phenyl-1-propanone gave (+)-(αR)-α-phenyl-4-morpholinepropanol in 87.3% yield. The intermediate α-phenyl-4-morpholinepropanol-borane complex was characterized by x-ray crystallog.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics