The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,10-Phenanthroline( cas:66-71-7 ) is researched.Synthetic Route of C12H8N2.Jannapu Reddy, Raju; Waheed, Md.; Haritha Kumari, Arram; Rama Krishna, Gamidi published the article 《Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides》 about this compound( cas:66-71-7 ) in Advanced Synthesis & Catalysis. Keywords: benzoxathiocino benzothiazocino triazole preparation; propargyl benzyl thiosulfonate organic azide tandem cycloaddition thiolation. Let’s learn more about this compound (cas:66-71-7).
A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51-94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61-74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on exptl. results and control experiments
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics