Delot, Marc; Carato, Pascal; Furman, Christophe; Lemoine, Amelie; Lebegue, Nicolas; Berthelot, Pascal; Yous, Said published the article 《Synthesis of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with potential topoisomerase I inhibitory activity》. Keywords: dihydrooxazolo indenoquinolinone Friedlander preparation antitumor.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.
A series of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones I (R1 = H, Me; R2 = H, Me, Ph, 4-Cl-Ph; R3 = H, MeO) were prepared by means of Friedlander condensations. The starting materials for the preparations were com. substituted 2-aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][1,3]oxazole-2,7(3H)-diones that were synthesized from 2(3H)-benzoxazolones or their N-Me analogs. Antitumor activity of the title compounds has been tested on DU145 human androgen-independent prostate cancer cells.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics