Application In Synthesis of 6-Acetylbenzo[d]oxazol-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Acyl benzoxazolinones. II. Preparation of some transformation products. Author is Bonte, Jean P.; Lesieur, Daniel; Lespagnol, Charles; Cazin, Jean C.; Cazin, Micheline.
Alcs. I (R = H, R1 = MeCHOH, EtCHOH, PhCHOH, PhCH2CHOH) were prepared in 85-90% yield by reducing I (R = H, R1 = Ac, EtCO, Bz, Ph-CH2CO) and had analgesic activity comparable to that of I (R = R1 = H). Alk. hydrolysis of I (R = H, Me; R1 = HCO, Ac, EtCO, Bz, PhCH2CO, 2-thenoyl) gave 2,4-HO(R1)C6H3NHR with loss of analgesic activity. Reaction of I (R = H, R1 = Ac) with R2CHO (R2 = Ph, p-ClC6H4, p-MeOC6H4, m-MeOC6-H4, 2,3,4-HO2C(MeO)2C6H2, PhCH:CH, 2-thienyl, p-O2NC6H4, m-O2NC6H4) gave I (R = H, R1 = R2CH:CHCO), which were reduced to I (R = H, R1 = R2CH2CH2CO), both with loss of analgesic activity.
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