The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Synthetic Route of C7H6BrI.Pan, Ming; Shao, Ying-Bo; Zhao, Qun; Li, Xin published the article 《Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations》 about this compound( cas:16004-15-2 ) in Organic Letters. Keywords: alkyl bromide quinazolinone alkylation phase transfer catalyst; axially chiral quinazolinone preparation enantioselective DFT. Let’s learn more about this compound (cas:16004-15-2).
A wide range of N-N axially chiral quinazolinone derivatives I (R1 = Ph, prop-1-en-2-yl, 3-chlorphenyl, etc.; R2 = Ph, 1-naphthyl, prop-1-ynyl, etc.; R3 = Ph, t-Bu, 3-bromophenyl, etc.; R4 = H, 7-Me, 6-I, 5-Cl, etc.) were prepared by phase-transfer catalysis in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. D. functional theory calculations provide insight into the mechanism.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics