Celik, Hayati; Buyukaga, Mahmure; Celebier, Mustafa; Turkoz Acar, Ebru; Baymak, Melek Sirin; Gokhan-Kelekci, Nesrin; Palaska, Erhan; Erdogan, Hakki published the article 《Determination of pKa Values of Some Benzoxazoline Derivatives and the Structure-Activity Relationship》. Keywords: ionization constant deprotonation benzoxazolinone derivative analgetic antiinflammatory drug SAR.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Recommanded Product: 54903-09-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.
The acid ionization constant (pKa) values of 2-(3H)-benzoxazolinone and its 17 derivatives were determined in buffered solutions by UV-vis spectrophotometry, potentiometry, and capillary zone electrophoresis techniques. The pKa values of the studied compounds were found to be in the range of 9.01 to 7.15. The advantages and limitations of each technique are discussed. The results suggest that the removal of a proton from the mol. occurred on the nitrogen atom of the 2-(3H)-benzoxazolinone ring and the analgesic/anti-inflammatory activities of the benzoxazolinone derivatives decrease when the pKa values of the compounds increase.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics