SDS of cas: 16004-15-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Efficient radiosynthesis and preclinical evaluation of [18F]FOMPyD as a positron emission tomography tracer candidate for TrkB/C receptor imaging. Author is Singleton, Thomas A.; Bdair, Hussein; Bailey, Justin J.; Choi, Sangho; Aliaga, Arturo; Rosa-Neto, Pedro; Schirrmacher, Ralf; Bernard-Gauthier, Vadim; Kostikov, Alexey.
Herein we report an efficient radiolabeling of a 18F-fluorinated derivative of dual inhibitor GW2580, with its subsequent evaluation as a positron emission tomog. (PET) tracer candidate for imaging of two neuroreceptor targets implicated in the pathophysiol. of neurodegeneration: tropomyosin receptor kinases (TrkB/C) and colony stimulating factor receptor (CSF-1R). [18F]FOMPyD was synthesized from a boronic acid pinacolate precursor via copper-mediated 18F-fluorination concerted with thermal deprotection of the four Boc groups on a diaminopyrimidine moiety in an 8.7±2.8% radiochem. yield, a radiochem. purity >99%, and an effective molar activity of 187±93 GBq/μmol. [18F]FOMPyD showed moderate brain permeability in wild-type rats (SUVmax = 0.75) and a slow washout rate. The brain uptake was partially reduced (ΔAUC40-90 = 11.6%) by administration of the nonradioactive FOMPyD (up to 30 μg/kg). In autoradiog., [18F]FOMPyD exhibits ubiquitous distribution in rat and human brain tissues with relatively high nonspecific binding revealed by self-blocking experiment The binding was blocked by TrkB/C inhibitors, but not with a CSF-1R inhibitor, suggesting selective binding to the former receptor. Although an unfavorable pharmacokinetic profile will likely preclude application of [18F]FOMPyD as a PET tracer for brain imaging, the concomitant one-pot copper-mediated 18F-fluorination/Boc-deprotection is a practical technique for the automated radiosynthesis of acid-sensitive PET tracers.
This literature about this compound(16004-15-2)SDS of cas: 16004-15-2has given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-4-iodobenzene) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics