Reference of 2-Bromopriopionaldehydediethylacetal. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles. Author is Walsh, John S.; Wang, Regina; Bagan, Edward; Wang, C. C.; Wislocki, Peter; Miwa, Gerald T..
Two approaches have been used to develop nonmutagenic 5-nitroimidazoles, both of which are based on knowledge of the likely mechanisms by which this class of compounds cause mutagenicity. The first approach involves incorporating readily oxidizable gallate derivatives into the mol. In one case, a very weakly mutagenic active antitrichomonal agent was obtained. The second approach involved incorporating a substituent at the C-4 position of the ring. This generally resulted in a large reduction in mutagenicity and a lowering of antitrichomonal activity in vitro. In certain cases, however, mutagenicity was dramatically reduced while moderate antitrichomonal activity was retained. For example, 1,2-dimethyl-4-(2-hydroxyethyl)-5-nitroimidazole (I) showed good antitrichomonal activity in vitro (ED50 = 2 μg/kg) while possessing only 4% of the mutagenicity of metronidazole.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Bromopriopionaldehydediethylacetal)Reference of 2-Bromopriopionaldehydediethylacetal, illustrating the importance and wide applicability of this compound(3400-55-3).
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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics