The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Safety of 1-(Bromomethyl)-4-iodobenzene.Yanai, Kei; Togo, Hideo published the article 《Novel preparation of N-arylmethyl-N-arylmethyleneamine N-oxides from benzylic bromides with zinc and isobutyl nitrite》 about this compound( cas:16004-15-2 ) in Tetrahedron. Keywords: nitrone preparation benzylic bromide zinc isobutyl nitrite. Let’s learn more about this compound (cas:16004-15-2).
Treatment of benzylic bromides with Zn and LiCl, followed by the reaction with i-Bu nitrite gave N-arylmethyl-N-arylmethyleneamine N-oxides in moderate yields [e.g., 4-methylbenzyl bromide → I (47%)]. The present reaction is a novel and simple method for the preparation of nitrones from benzylic bromides, although the yields are moderate.
In some applications, this compound(16004-15-2)Safety of 1-(Bromomethyl)-4-iodobenzene is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics