Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Ligand-acceleration by a chiral modifier in the enantioselective hydrogenation of methyl acetoacetate on a Raney nickel catalyst: effect of a modifier configuration.Recommanded Product: 53562-86-0.
Reaction rate and enantioselectivity of asym. hydrogenation of Me acetoacetate were studied over Raneynickel catalysts modified with (R,R)-tartaric acid, malic acid, or succinic acid to reveal the impacts of the modifier configuration. Catalysts comodified with two different acids were also examined to confirm the conclusions. From anal. of the enantiomer ratio of the hydrogenation product and initial reaction rate, tartaric acid (TA) was found to have dual functions as the modifier during the hydrogenation; effective suppression of the racemic catalysis on bare Ni surface and extensive enantiodifferentiating ligand acceleration by adsorbed TA. It was demonstrated that each adsorbed chiral modifier mol. independently takes part in the enantiospecific hydrogenation.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics