Safety of (S)-Methyl 3-hydroxybutanoate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Highly Effective Chiral Ortho-Substituted BINAPO Ligands (o-BINAPO): Applications in Ru-Catalyzed Asymmetric Hydrogenations of β-Aryl-Substituted β-(Acylamino)acrylates and β-Keto Esters. Author is Zhou, Yong-Gui; Tang, Wenjun; Wang, Wen-Bo; Li, Wenge; Zhang, Xumu.
A novel family of chiral ortho-substituted BINAPO ligands (o-BINAPO) I (R = H, Me, Ph, 3,5-Me2C6H3; R1 = Ph, 3,5-Me2C6H3) were prepared from the corresponding binaphthols and diarylchlorophosphines; complexes of I with [(p-cymene)RuCl2]2 were highly efficient catalysts for asym. hydrogenation of β-aryl-substituted β-(acylamino)acrylates R2C(AcNH):CHCO2R3 (R2 = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 4-MeOC6H4, 2-MeC6H4, 2-MeOC6H4; R3 = Me, Et) and β-aryl-substituted β-keto esters R4COCH2CO2R5 (R4 = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 4-MeOC6H4, 2-MeC6H4, 2-MeOC6H4, Me, ClCH2; R5 = Me, Et) to give nonracemic β-amino acid esters R2CH(NHAc)CH2CO2R3 (R2 = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 4-MeOC6H4, 2-MeC6H4, 2-MeOC6H4; R3 = Me, Et) and β-hydroxy esters R4CH(OH)CH2CO2R5 (R4 = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 4-MeOC6H4, 2-MeC6H4, 2-MeOC6H4, Me, ClCH2; R5 = Me, Et). While most asym. hydrogenation catalysts are effective only with single stereoisomers of β-amidoesters, hydrogenation catalysts prepared from I and [(p-cymene)RuCl2]2 hydrogenated E/Z mixture of β-aryl-substituted β-(acylamino)acrylates enantioselectively to give β-(acetylamino)esters in high enantiomeric excesses. E.g., Me 3-phenyl-3-acetylamino-2-propenoate PhC:NHAcCHCO2Me (prepared from Me 3-phenyl-3-oxopropanoate by addition of ammonium acetate, precipitation, and acylation with acetic anhydride) undergoes enantioselective hydrogenation in ethanol at 80 psi and 50° in the presence of a ruthenium catalyst prepared from I (R = 3,5-Me2C6H3; R1 = Ph) and [(p-cymene)RuCl2]2 to give PhCH(NHAc)CH2CO2Me in 99% ee.
When you point to this article, it is believed that you are also very interested in this compound(53562-86-0)Safety of (S)-Methyl 3-hydroxybutanoate and due to space limitations, I can only present the most important information.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics