Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of chalcones condensed with an 1,3-azole ring using a SOCl2/EtOH catalytic system.Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.
A series of substituted heterocyclic chalcones were synthesized by aldol condensation of corresponding heterocyclic ketones (preparation shown) aromatic aldehydes, in the presence of thionyl chloride-EtOH as a catalyst. The reaction was stereoselective and only trans-isomers were obtained in excellent yields and purity. Three out of 7 prepared chalcones (I, R = H, OH, OMe) were tested in vitro for their antitumor activity. They were found to have IC50 values ranging between 10-15 μM.
In some applications, this compound(54903-09-2)Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics