Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Asymmetric Hydrogenation of Amino Ketones Using Chiral RuCl2(diphosphine)(1,2-diamine) Complexes.Product Details of 53636-17-2.
Chiral RuCl2(diphosphine)(1,2-diamine) complexes catalyzed the asym. hydrogenation of amino ketones. E.g., hydrogenation of MeCOCH2NMe2 in presence of trans-RuCl2[(R)-xylbinap][(R)-daipen] gave 79% (S)-MeCH(OH)CH2NMe2. Also prepared by this catalytic hydrogenation system were (R)-denopamine, (R)-fluoxetine, and BMS 181100.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics