The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromopriopionaldehydediethylacetal(SMILESS: CC(Br)C(OCC)OCC,cas:3400-55-3) is researched.Electric Literature of C9H7NO3. The article 《Base-catalyzed dehydrobromination of several α-bromoacetals》 in relation to this compound, is published in Canadian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:3400-55-3).
Base-catalyzed dehydrohalogenation with tert-BuOK in tert-BuOH of the acetals obtained from homologs of α-bromoacetaldehyde and ethylene glycol[2-(α-bromoalkyl)-1,3-dioxolanes] or 1,3,-propanediol[2-(α-bromoalkyl)-1,3-dioxane] provides the corresponding ketene acetal, in some cases exclusively and in others as the major product along with a smaller proportion of the α,β-unsaturated acetal. In contrast, similar dehydrohalogenation conditions convert the acetals obtained from homologs of α-bromoacetaldehyde and monohydroxy alcs, to the α,β-unsaturated acetals, in some cases exclusively, and in others as the major product accompanied by a smaller proportion of the corresponding ketene acetal. The preference for the ketene acetal formation from the 2-(α-bromoalkyl)-1,3-dioxolanes (the ethylene acetals) is believed due to greater ease of approach by base to the methine proton as a result of the restricted shape of the 1,3-dioxolane ring. Approach by base to the methine proton of the α-bromoalkyl dialkylacetals is more hindered by the two alkoxy groups, which cause preferred attack by base at the β proton to provide the α,β-unsatd acetal. The proportion of α,β-unsaturated acetal obtained from base-catalyzed dehydrohalogenation of 2-(α-bromoalkyl)-1,3-dioxolanes can be greatly increased if the reaction is carried out in Me2SO. This marked change in proportion of products is thought to be due to a change in mechanism occasioned by the Me2SO.
In some applications, this compound(3400-55-3)Application In Synthesis of 2-Bromopriopionaldehydediethylacetal is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics