Synthetic Route of C7H6BrI. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Synthesis of 1,2,3-triazole benzophenone derivatives and evaluation of in vitro sun protection, antioxidant properties, and antiproliferative activity on HT-144 melanoma cells. Author is Dias, Maria C. F.; de Sousa, Bianca L.; Ionta, Marisa; Teixeira, Robson R.; Goulart, Thiago Q.; Ferreira-Silva, Guilherme A.; Pilau, Eduardo J.; dos Santos, Marcelo H..
Two series of 1,2,3-triazole-benzophenone derivatives I [R = R1 = Ph, 3-MeC6H4, 4-ClC6H4, etc.] and II [R2 = Ph, 2-pyridyl, 4-BrC6H4, etc.] were synthesized and their antioxidant, anticancer and photoprotective effects evaluated. For the compounds synthesis, 4,4′-dihydroxybenzophenone and 2,4-dihydroxybenzophenone were propargylated and afforded alkynes, bis(4-(prop-2-yn 1-yloxy))benzophenone and (2-hydroxy-4-(prop-2-yn-1-yloxy))benzophenone, resp. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between the alkynes and several benzyl azides gave the compounds I and II with yields ranging from 35 to 95%. Compounds I and II at the concentration of 0.2μg mL-1 (a no-cytotoxic concentration) exhibited a solar protection factor (SPF) comparable to pos. control benzophonen-3 (BP-3). Concerning their antioxidant and cytotoxic effects, the derivatives from 2,4-dihydroxybenzophenone showed high in vitro antioxidant effects as well as cytotoxicity against A549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-144 (metastatic melanoma) cell lines, without significant cytotoxicity to a non-cancerous cell line. Derivatives II [R2 = Ph, 4-MeC6H4, 2,4-F2C6H3] induced cell death and cell cycle arrest at G1/S in HT-144 melanoma cells.
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Piperazines – an overview | ScienceDirect Topics