Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Cationic BINAP-Ru(II) Halide Complexes: Highly Efficient Catalysts for Stereoselective Asymmetric Hydrogenation of α- and β-Functionalized Ketones. Author is Mashima, Kazushi; Kusano, Koh-hei; Sato, Naomasa; Matsumura, Yoh-ichi; Nozaki, Kyoko; Kumobayashi, Hidenori; Sayo, Noboru; Hori, Yoji; Ishizaki, Takero.
Cationic ruthenium-BINAP complexes of the formula [RuX[(S)-BINAP](arene)]Y, where X = Cl, Br, I; Y = Cl, Br, I, BF4, B(C6H5)4; arene = benzene, p-cymene, Et benzoate, and their enantiomers have been prepared by the reaction of arene-ruthenium halide complexes with (S)-BINAP or (R)-BINAP [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]. Structures of the complexes were established by spectroscopy, conductivity, and a single-crystal x-ray anal. BINAP derivatives with various substituents at the para and meta positions of four Ph rings on phosphorus atoms and their cationic Ru(II) complexes have also been synthesized. These BINAP-Ru(II) complexes have been used as catalysts for the asym. hydrogenation of various unsaturated organic compounds such as α- and β-keto esters, allylic alcs., and α,β-unsaturated carboxylic acids in excellent diastereo- and/or enantioselectivities. Catalytic activities and stereoselectivities depend highly on reaction conditions such as solvent, temperature, and additives. Variation of halogen ligands bound to ruthenium atom and substituents on four Ph rings of BINAP also have exerted remarkable effects on the efficiency of the catalysis. Asym. hydrogenation of methyl(±)-2-(benzamidomethyl)-3-oxobutanoate catalyzed by the species derived from [RuI2(p-cymene)]2 and 3,5-(Me3C)2-BINAP afforded the corresponding syn-(2S,3R)-I in 98% de and 99% ee.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics