Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – An Asian Journal called Syntheses of 1H-Indoles, Quinolines, and 6-Membered Aromatic N-Heterocycle-Fused Scaffolds via Palladium(II)-Catalyzed Aerobic Dehydrogenation under Alkoxide-Free Conditions, Author is Yoo, Hyung-Seok; Yang, Yo-Sep; Kim, Soo Lim; Son, Seung Hwan; Jang, Yoon Hu; Shin, Jeong-Won; Kim, Nam-Jung, which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Application of 2343-22-8.
Aromatic N-heterocycle-fused scaffolds such as indoles and quinolines I (R1 = H, 5-Me, 6-NH2, etc.; R2 = H, 2-Me, 2-C6H5, etc.; X = C, N) are important core structures found in various bioactive natural products and synthetic compounds Recently, various dehydrogenation methods with the help of alkoxides, known to significantly promote dihydro- or tetrahydro-heterocycles to be oxidized, were developed for the heterocycle synthesis. However, these approaches are sometimes unsuitable due to resulting undesired side reactions such as reductive dehalogenation. Herein, expedient syntheses of 1H-indoles, quinolines, and 6-membered N-heterocycle-fused scaffolds from their hydrogenated forms through palladium(II)-catalyzed aerobic dehydrogenation under alkoxide-free conditions are reported. A total of 48 compounds were successfully synthesized with a wide range of functional groups including halogens (up to 99% yield). These methodologies provide facile routes for various privileged structures possessing aromatic N-heterocycles without the help of alkoxides, in highly efficient manners.
After consulting a lot of data, we found that this compound(2343-22-8)Application of 2343-22-8 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics