The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Application In Synthesis of 5-Fluoroindoline.Jin, Ning; Pan, Changduo; Zhang, Honglin; Xu, Pan; Cheng, Yixiang; Zhu, Chengjian published the article 《Rhodium-Catalyzed Direct C7 Alkynylation of Indolines》 about this compound( cas:2343-22-8 ) in Advanced Synthesis & Catalysis. Keywords: triisopropylsilylethynylindolinylethanone preparation; acetylindoline TIPS EBX alkynylation rhodium catalyst. Let’s learn more about this compound (cas:2343-22-8).
An efficient rhodium(III)-catalyzed direct C7 alkynylation of indoline C-H bonds e.g., I with the alkynylated hypervalent iodine reagents II (R = triisopropylsilyl, t-butyldimethylsilyl, trimethylsilyl, triethylsilyl) has been developed. This reaction proceeds smoothly under mild conditions over a wide structural scope with high site-selectivity and excellent functional-group tolerance.
After consulting a lot of data, we found that this compound(2343-22-8)Application In Synthesis of 5-Fluoroindoline can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics