Synthetic Route of C7H6BrI. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Synthesis of core-corona polymer microsphere-supported cinchonidinium salt and its application to asymmetric synthesis. Author is Ullah, Wali Md.; Thao, Nguyen Thi Phuong; Sugimoto, Takuya; Haraguchi, Naoki.
We have successfully synthesized a sulfonated core-corona polymer microsphere by the surface-initiated ATRP (SI-ATRP) of achiral vinyl monomer and phenylsulfonated styrene with monodispersed polymer microsphere having benzyl chloride moiety prepared via precipitation polymerization as a macroinitiator, followed by the treatment of NaOH. N-(9-Anthracenemethyl)-cinchonidinium chloride was successfully immobilized onto the side chain of corona of the sulfonated core-corona polymer microsphere by ion exchange to afford a core-corona polymer microsphere-supported chiral cinchonidinium salt. The core-corona polymer microsphere-supported chiral cinchonidinium salts were used as polymeric chiral organocatalysts for the asym. alkylation reaction of N-(diphenylmethyl)glycine tert-Bu ester. We found that the size of core, nature and length of corona, grafting d., as well as the degree of crosslinking significantly affected the catalytic reactivity. Among them, 5d20hC20 [the copolymer of divinylbenzene, 2-hydroxyethyl methacrylate, and 4-vinylbenzyl chloride with grafted hydrolyzed poly(styrene/phenyl 4-vinylsulfonate) blocks] showed good reactivity and excellent enantioselectivity (up to <99%), higher than those corresponding nonpolymeric cinchonidinium salt, microsphere catalyst M-Cat, as well as linear polymeric catalyst St0Cat100. 5D20hC20 could be reused several times without loss of enantioselectivity. Different reactions of this compound(1-(Bromomethyl)-4-iodobenzene)Synthetic Route of C7H6BrI require different conditions, so the reaction conditions are very important.
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