Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Convenient preparation of BINAP-ruthenium(II) complexes for catalyzing the asymmetric hydrogenation of functionalized ketones.Computed Properties of C5H10O3.
Ligand exchange between [RuCl2(benzene)]2 or RuCl2[Sb(C6H5)3]3 and (R)- or (S)-BINAP [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene] produces BINAP-Ru(II) complexes which act as catalysts for the highly enantioselective hydrogenation of functionalized ketones, e.g., AcCH2CO2Me to R-MeCH(OH)CH2CO2Me.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics