The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Discovery of Novel Thiazole Carboxamides as Antifungal Succinate Dehydrogenase Inhibitors, the main research direction is thiazole carboxamide preparation antifungal succinate dehydrogenase inhibitor; fungicide; molecular docking; succinate dehydrogenase inhibitor; thiazole carboxamide.Category: piperazines.
To contribute mol. diversity for novel fungicide development, a series of novel thiazole carboxamides were rationally designed, synthesized, and characterized with the succinate dehydrogenase (SDH) as target. Bioassay indicated that compound 6g showed the similar excellent SDH inhibition as that of Thifluzamide with IC50 of 0.56 mg/L and 0.55 mg/L, resp. Some derivatives displayed improved in vitro fungicidal activities against Rhizoctonia cerealis and Sclerotinia sclerotiorum with EC50 of 1.2-16.4 mg/L and 0.5-1.9 mg/L. Surprisingly, 6g showed promising in vitro fungicidal activities against R. cerealis and S. sclerotiorum with EC50 of 6.2 and 0.6 mg/L, resp., which was superior to Thifluzamide with the EC50 of 22.1 and 4.4 mg/L, resp. Addnl., compounds 6c and 6g displayed excellent in vivo fungicidal activities against S. sclerotiorum on Brassica napus L. leaves with protective activity of 75.4% and 67.3% at 2.0 mg/L, resp., while Thifluzamide without activity at 5.0 mg/L. Transcriptomic anal. of S. sclerotiorum treated with 6g by RNA sequencing indicated the down-regulation of succinate dehydrogenase gene SDHA and SDHB, and the inhibition of the TCA-cycle.
The article 《Discovery of Novel Thiazole Carboxamides as Antifungal Succinate Dehydrogenase Inhibitors》 also mentions many details about this compound(2343-22-8)Category: piperazines, you can pay attention to it, because details determine success or failure
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics