Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones, published in 1979-04-30, which mentions a compound: 54903-09-2, Name is 6-Acetylbenzo[d]oxazol-2(3H)-one, Molecular C9H7NO3, Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

Photo-Fries rearrangements of N-acyl-2,3-dihydrobenzoxazol-2-ones (I; R = Ac, COEt, COPr, COCHMe2, Bz, COC6H4Me-p) are described. Irradiation of I in MeCN afforded a mixture of 2-acyl-2,3-dihydrobenzoxazol-2-one and 6-acyl-2,3-dihydrobenzoxazol-2-one together with other minor products. However, I (R = H, Me) were very photostable. The reaction scheme involving Norrish type I dissociation is discussed.

The article 《Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones》 also mentions many details about this compound(54903-09-2)Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Reger, Daniel L.; Mason, Scott S.; Rheingold, Arnold L.; Ostrander, Robert L. published an article about the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3,SMILESS:[BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+] ).Electric Literature of C9H10BKN6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:18583-60-3) through the article.

The reactions of 2 equiv of K[H2B(pz)2], K[HB(pz)3], K[B(pz)4], K[H2B(3,5-Me2pz)2], K[HB(3,5-Me2pz)3], and K[B(3-Mepz)4] with CdCl2 give the resp. [poly(pyrazolyl)borato]2Cd complexes in high yields. A similar reaction with a 1/1 mixture of K[HB(3,5-Me2pz)3] and either K[H2B(pz)2] or K[B(pz)4] yields [HB(3,5-Me2pz)3]Cd[H2B(pz)2] (7) or [HB(3,5-Me2pz)3]Cd[B(pz)4] (8), resp. The solid-state structures of [B(pz)4]2Cd (3), [HB(3,5-Me2pz)3]2Cd (5), and [B(3-Mepz)4]2Cd.2C7H8 (6) were determined crystallog. All 3 complexes show a distorted octahedral arrangement of the N donor atoms, with the Cd atom located on a center of symmetry. For 5, all Cd-N bonding distances are equal, but for 3 and 6, 3 different Cd-N bond distances, with the differences being as large as 0.103 Å for 3, are observed Variable-temperature 1H NMR spectra show that complexes 1, 3, 4, and 6-8 are dynamic in solution For 3, 6, and 8 all of the pyrazolyl rings of the tetrakis(pyrazolyl)borate ligands are equivalent at high temperatures with a 3/1 pattern observed at low temperatures A mechanism that exchanges a coordinated with the noncoordinated pyrazolyl ring for the tetrakis(pyrazolyl)borate ligands is presented to explain these data. For 7 at low temperatures each resonance type for the [HB(3,5-Me2pz)3]- ligand appears as 2 resonances in a 2/1 ratio, resonances that coalesce at higher temperatures The pyrazolyl ring resonances for the [H2B(pz)2]- ligand resonances remain equivalent at low temperatures, indicating a 5-coordinate, square pyramidal arrangement of the N donor atoms. For 8, the resonances for the [HB(3,5-Me2pz)3]- ligand remain equivalent at low temperatures, indicating that the complex in 6-coordinate. Crystal data: [B(pz)4]2Cd, monoclinic, space group P21/c, Z = 2, R = 3.79%; [HB(3,5-Me2pz)3]2Cd, rhombohedral, space group R3̅, Z = 3, R = 5.50%; [B(3-Mepz)4]2Cd.2C7H8, monoclinic, space group P21/c, Z = 2, R = 7.72%.

The article 《Syntheses, structures, 113Cd solution NMR chemical shifts, and investigations of fluxional processes of bis[poly(pyrazolyl)borato]cadmium complexes》 also mentions many details about this compound(18583-60-3)Electric Literature of C9H10BKN6, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric reactions catalyzed by chiral metal complexes. XLIX. Synthesis of atropisomeric biphenylbisphosphine. 6,2′-Bis(diphenylphosphino)-3-methoxy-2,4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and its use in ruthenium(II)-catalyzed asymmetric hydrogenation of a 3-oxo ester, published in 1991-11-30, which mentions a compound: 53562-86-0, mainly applied to asym hydrogenation oxobutanoate catalyst biphenylbisphosphineruthenium; atropisomeric biphenylbisphosphine ligand synthesis, Quality Control of (S)-Methyl 3-hydroxybutanoate.

New atropisomeric biphenylbisphosphines, 6,2′-bis(diphenylphosphino)-3-methoxy-2,4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and 2,2′-bis(diphenylphosphino)-4,4′,6,6′-tetrakis(trifluoromethyl)-1,1′-biphenyl (BIFUP), were prepared from 2,3,5-Br(CF3)2C6H2NO2. The FUPMOP-Ru(II) complex was an excellent catalyst for the asym. hydrogenation of MeCOCH2CO2Me.

The article 《Asymmetric reactions catalyzed by chiral metal complexes. XLIX. Synthesis of atropisomeric biphenylbisphosphine. 6,2′-Bis(diphenylphosphino)-3-methoxy-2,4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and its use in ruthenium(II)-catalyzed asymmetric hydrogenation of a 3-oxo ester》 also mentions many details about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Convenient preparation of BINAP-ruthenium(II) complexes for catalyzing the asymmetric hydrogenation of functionalized ketones.Computed Properties of C5H10O3.

Ligand exchange between [RuCl2(benzene)]2 or RuCl2[Sb(C6H5)3]3 and (R)- or (S)-BINAP [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene] produces BINAP-Ru(II) complexes which act as catalysts for the highly enantioselective hydrogenation of functionalized ketones, e.g., AcCH2CO2Me to R-MeCH(OH)CH2CO2Me.

The article 《Convenient preparation of BINAP-ruthenium(II) complexes for catalyzing the asymmetric hydrogenation of functionalized ketones》 also mentions many details about this compound(53562-86-0)Computed Properties of C5H10O3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about DMSO/t-BuONa/O2-Mediated Aerobic Dehydrogenation of Saturated N-Heterocycles, the main research direction is quinoline preparation; tetrahydroquinoline sodium tert butoxide dimethyl sulfoxide oxidative dehydrogenation; isoquinoline preparation; tetrahydroisoquinoline sodium tert butoxide dimethyl sulfoxide oxidative dehydrogenation; indole preparation; indoline sodium tert butoxide dimethyl sulfoxide oxidative dehydrogenation.Application of 2343-22-8.

Aromatic N-heterocycles such as quinolines I [R1 = H, 8-Cl, 6-OMe, etc.; R2 = H, 3-Me, 4-Ph, etc. X = N; Y = CH2], isoquinolines I [R1 = H; R2 = H, 1-Ph; X = CH2; Y = N] and indoles II [R1 = H, 5-F, 4-Br, etc.; R2 = H, 2-Me; Y = CH2, N] were synthesized via a sodium tert-butoxide promoted oxidative dehydrogenation of the saturated heterocycles in DMSO solution This reaction proceeded under mild reaction conditions with a good functional group tolerance. Mechanistic studies suggested a radical pathway involved hydrogen abstraction of dimsyl radicals from the N-H bond or α-C-H of the substrates, and subsequent oxidation of the nitrogen or α-aminoalkyl radicals.

The article 《DMSO/t-BuONa/O2-Mediated Aerobic Dehydrogenation of Saturated N-Heterocycles》 also mentions many details about this compound(2343-22-8)Application of 2343-22-8, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic and optoelectronic investigations of 3,8-bis(3,4-(ethylenedioxy)thien-2-yl)-1,10-phenanthroline, the main research direction is ethylenedioxythien phenanthroline Spectroscopy optoelectronics.Application of 66-71-7.

1,10-Phenanthroline-based luminescent materials play an important role as an excellent class of optoelectronic materials due to their remarkable and novel attributes for optoelectronic applications. There is an enormous demand of luminescent materials in many fields. The foremost objective of this paper is to synthesize fluorescent derivatives of 1,10-phenanthroline. The electronic effect of the substituents on the heteroaromatic ligand has been reviewed in solid state. These ligands were characterized by electrochem. study and spectroscopically. The value of energy band gap is estimated to be 3.0-4.5 eV for synthesized compounds Photophys. features were analyzed through photoluminescence spectrometer, which indicates a strong impact of the substituents on the photoluminescent properties of the phenanthroline ligand. Upon excitation in UV region, intense broad band appeared in emission spectra of synthesized compounds lie in visible region which is further supported by CIE color coordinates. The detailed explanation about the geometry and frontier MOs calculation was carried out with the help of Avogadro and ORCA software.

The article 《Spectroscopic and optoelectronic investigations of 3,8-bis(3,4-(ethylenedioxy)thien-2-yl)-1,10-phenanthroline》 also mentions many details about this compound(66-71-7)Application of 66-71-7, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new cationic BINAP-ruthenium(II) complexes and their use in asymmetric hydrogenation [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]》. Authors are Mashima, Kazushi; Kusano, Kohhei; Ohta, Tetsuo; Noyori, Ryoji; Takaya, Hidemasa.The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Quality Control of (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

Reaction of [RuX2(arene)]2 with (S)-BINAP gives cationic BINAP-ruthenium complexes I (X = Cl, Br, iodo; Z = Cl, Br, iodo, BF4, BPh4; arene = C6H6, p-MeC6H4CHMe2) which are efficient catalyst precursors for enantioselective hydrogenation of various prochiral alkenic and ketonic substrates; a crystal structure of I (X = Cl, Z = BF4) was obtained.

The article 《Synthesis of new cationic BINAP-ruthenium(II) complexes and their use in asymmetric hydrogenation [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]》 also mentions many details about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Structural characterization and variable temperature 1H NMR of monoporphyrinate samarium(III) and erbium(III) complexes, the main research direction is samarium erbium porphyrinate pyrazolylborate preparation NMR.Category: piperazines.

Two samarium(III) and erbium(III) monoporphyrinate complexes stabilized by anionic hydrotris(pyrazolyl)borate (TpH) were prepared and characterized by elemental anal., UV-visible, IR, and mass spectra. Structural anal. revealed that seven N atoms from porphyrin dianion and TpH- coordinated to the lanthanide ions. The 1H NMR spectra showed Sm3+ has a slight effect on proton chem. shifts, whereas Er3+ has a heavy effect that leads to the up-field and downfield shift of proton chem. shift. The variable temperature 1H NMR reveals that the chem. shifts of protons of all complexes are temperature-dependent.

The article 《Structural characterization and variable temperature 1H NMR of monoporphyrinate samarium(III) and erbium(III) complexes》 also mentions many details about this compound(18583-60-3)Category: piperazines, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Ji, Jianguo; Schrimpf, Michael R.; Sippy, Kevin B.; Bunnelle, William H.; Li, Tao; Anderson, David J.; Faltynek, Connie; Surowy, Carol S.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. published the article 《Synthesis and Structure-Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists》. Keywords: diazabicycloheptane asym preparation nicotinic acetylcholine receptor agonist SAR; structure activity relationship diazabicycloheptane nicotinic acetylcholine receptor agonist.They researched the compound: 2,3-Dichloro-5-iodopyridine( cas:97966-01-3 ).Reference of 2,3-Dichloro-5-iodopyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:97966-01-3) here.

A series of novel, potent neuronal nicotinic acetylcholine receptor (nAChR) ligands I and II (R1 = H, Me, Cl, Br; R2 = Me, cyano, Br, OMe, CCH, 2-oxazolyl, etc.) derived from 3,6-diazabicyclo[3.2.0]heptane have been synthesized and evaluated for binding affinity and agonist activity at the α4β2 nAChR subtype. Structure-activity relationship studies of these novel nAChR ligands focused on substitution effects on the pyridine ring, as well as stereo- and regiochem. influences of the 3,6-diazabicyclo[3.2.0]heptane core. Small 5-substituents on the pyridine ring had a modest impact on the binding affinities and functional activities. 6-Bromo, 6-chloro, and 6-Me substituents on the pyridine ring led to increased binding affinities and improved functional activities. Most of the 6-N-pyridinyl-substituted 3,6-diazabicyclo[3.2.0]heptanes are selective for the α4β2 nAChR subtype. Compounds (1R,5S)-I (R1 = H, R2 = cyano), (1R,5S)-I [R1 = H, R2 = C(:NH)NHOH], and III were virtually inactive as agonists at the hα3β4 nAChR but retained potency and efficacy at the hα4β2 nAChR subtype. 3-N-Pyridinyl-substituted series demonstrated more complex SAR. (1R,5R)-II (R1 = Me, R2 = cyano), (1R,5R)-II (R1 = Cl, R2 = Me), and (1R,5R)-II (R1 = R2 = Cl) were found to be much more potent at the hα3β4 nAChR subtype, whereas (1R,5R)-II (R1 = R2 = Me) and (1R,5R)-II (R1 = Cl, R2 = H) were very selective at the hα4β2 nAChR subtype. The SAR studies of these novel ligands led to the discovery of several compounds with interesting in vitro pharmacol. profiles.

The article 《Synthesis and Structure-Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists》 also mentions many details about this compound(97966-01-3)Reference of 2,3-Dichloro-5-iodopyridine, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity. Author is Ivanova, Yordanka; Momekov, Georgi; Petrov, Ognyan.

The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone (I), its N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone was also synthesized and its influence on cytotoxic activity was investigated.

The article 《Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity》 also mentions many details about this compound(54903-09-2)Synthetic Route of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics