Month: April 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Spontaneous symmetry breaking in the formation of a dinuclear gadolinium semiquinonato complex: synthesis, high-field EPR studies, and magnetic properties.Computed Properties of C9H10BKN6.

The synthesis and characterization of an asym. dinuclear gadolinium(III) semiquinonato complex, [Gd2(HBPz3)2(dtbsq)4]·CHCl3 (1; HBPz3 = hydrotris(pyrazolyl)borate, dtbsq = 3,5-di-tert-butyl-o-semiquinone), is reported. The crystal structure of 1 was determined at room temperature It crystallizes in the triclinic system space group P1̅, with a 16.735(5), b 17.705(5), c 19.553(5) Å, α 99.680(5), β 109.960(5), γ 107.350(5)°, Z = 2 and R = 9.96. The structure of 1 consists of a dinuclear asym. unit in which the two gadolinium(III) ions have coordination numbers of eight and nine. Three of the dioxolene mols. act as asym. bridging ligands, while the 4th mol. behaves as a bidentate ligand towards a single metal ion. The magnetic properties of 1 were investigated by susceptibility measurements and high-field ESR (HF-EPR) spectroscopy. They revealed an S = 0 ground spin state with excited states of higher spin very close in energy and a small neg. zero-field splitting with a transverse anisotropy term for a S = 7 state.

The article 《Spontaneous symmetry breaking in the formation of a dinuclear gadolinium semiquinonato complex: synthesis, high-field EPR studies, and magnetic properties》 also mentions many details about this compound(18583-60-3)Computed Properties of C9H10BKN6, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Noyori, Ryoji; Ohkuma, Takeshi; Kitamura, Masato; Takaya, Hidemasa; Sayo, Noboru; Kumobayashi, Hidenori; Akutagawa, Susumu researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Quality Control of (S)-Methyl 3-hydroxybutanoate.They published the article 《Asymmetric hydrogenation of β-keto carboxylic esters. A practical, purely chemical access to β-hydroxy esters in high enantiomeric purity》 about this compound( cas:53562-86-0 ) in Journal of the American Chemical Society. Keywords: exo ester asym hydrogenation ruthenium. We’ll tell you more about this compound (cas:53562-86-0).

Q = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl. Although Ru(OAc)2(R)-Q was ineffective as a catalyst for asym. hydrogenation of MeCOCH2CO2Me, RuX2 (X = Cl, Br, I) complexes with (R)- or (S)-Q were highly effective for RCOCH2CO2R1 (R, R1 = Me, Me; Me, Et; Me, Me2CH; Me, Me3C; Et, Me; Bu, Me; Me2CH, Me; Ph, Et) giving up to 99% yields with up to 99% enantiomeric excess.

The article 《Asymmetric hydrogenation of β-keto carboxylic esters. A practical, purely chemical access to β-hydroxy esters in high enantiomeric purity》 also mentions many details about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 18583-60-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about A Heterobimetallic Vanadium-Manganese Complex as a Model for the Structural Dynamics in Oxo-Bridged Metal Dimers. Author is Dean, Norman S.; Cooper, Jennifer; Czernuszewicz, Roman S.; Ji, David; Carrano, Carl J..

The heterobimetallic complex [LV(μ-O)(μ-OAc)2MnL] (L = hydridotris(pyrazolyl)borate, 1) was synthesized and characterized. X-ray crystal structural anal. of 1 gave the following parameters: C24H29B2N13O5VMn, space group Cmc21, a 13.364(2), b 17.383(3), c 14.132(3) Å, Z = 4. An anal. of the structure, optical and resonance Raman spectroscopies, and magnetic measurements indicates that a VIV:O···MnII valence formulation is the best description of the oxo-bridged core in 1, although other resonance forms must also contribute.

The article 《A Heterobimetallic Vanadium-Manganese Complex as a Model for the Structural Dynamics in Oxo-Bridged Metal Dimers》 also mentions many details about this compound(18583-60-3)Related Products of 18583-60-3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Tridentate acylhydrazone copper(II) complexes with heterocyclic bases as coligands. Synthesis, spectroscopic studies, crystal structure and cytotoxicity assays.Recommanded Product: 66-71-7.

Two new pentacoordinated copper(II) hydrazone coordination compounds with 2,2′-bipyridine (i) or 1,10-phenanthroline (ii) as coligands were synthesized and characterized in the solid state and in solution by spectroscopic methods (FTIR, Raman, UV-visible, EPR). Single crystal x-ray studies show that they have closely related mol. structures with the copper center in a distorted square pyramidal O2N3 environment. The N-acylhydrazone, [4-hydroxy-NN-(E)2-hydroxy-3-methoxybenzylidene]benzohydrazide, H2L, coordinates tridentate through its ONO donor atoms as monoanion (HL-) in the cationic complex (i), [Cu(HL)(bipy)](NO3). During the period that takes the synthesis reaction of compound (ii), [Cu(L)(o-phen)] to complete, keto-amine to enol-imine tautomerization of H2L occurs and the hydrazone coordinates tridentate as dianionic ligand (L2-). The fivefold coordination sphere of the complexes is completed with the nitrogen atoms of the resp. coligands. Cytotoxicity studies against bone (MG-63, IC50(I) = 5.6 ± 1.0, IC50(II) = 3.5 ± 0.3), breast (MCF7, IC50(I) = 10.8 ± 1.9, IC50(II) = 4.0 ± 1.3), (MDA-MB-231, IC50(I) = 11.4 ± 0.6, IC50(II) = 5.3 ± 0.2) and lung cancer cells (A549, IC50(I) = 7.7 ± 0.7, IC50(II) = 7.0 ± 0.4) reveals increased effectiveness of both complexes compared with the free ligand, the copper nitrate salt and the reference metallodrug cisplatin (CDDP).

The article 《Tridentate acylhydrazone copper(II) complexes with heterocyclic bases as coligands. Synthesis, spectroscopic studies, crystal structure and cytotoxicity assays》 also mentions many details about this compound(66-71-7)Recommanded Product: 66-71-7, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 53562-86-0, is researched, SMILESS is C[C@H](O)CC(OC)=O, Molecular C5H10O3Journal, Carbon called Reduced graphene oxide supported chiral Ni particles as magnetically reusable and enantioselective catalyst for asymmetric hydrogenation, Author is Ding, Chao; Wei, Weili; Sun, Hanjun; Ding, Jinhua; Ren, Jinsong; Qu, Xiaogang, the main research direction is reduced graphene oxide supported nickel magnetically reusable enantioselective catalyst; asym hydrogenation enantioselective reduced graphene oxide supported nickel.Safety of (S)-Methyl 3-hydroxybutanoate.

A reduced graphene oxide (rGO) supported chiral-modified Ni catalyst was synthesized, characterized and employed for asym. hydrogenation. The prepared hybrid catalyst could produce each enantiomer with D- or L-tartaric acid as chiral modifier and exhibited a high TOF (20160 h-1) and enantioselectivity (enantiomeric excess, 98.5%) for asym. hydrogenation of Me acetoacetate. The high catalytic activity and enantioselectivity were mainly attributed to the unique properties of the support rGO, as it had a large sp. surface area to sustain and stabilize Ni particles and its high charge carrier mobility could enable the readily transfer of electrons in the reaction process. Besides, the catalyst could also gain an enhanced reactant sorption with the support of rGO, thus achieved a greatly catalysis enhancement. The ferromagnetism of Ni made the catalyst easier for separation and reuse. The catalytic and recycling performance of the prepared chiral Ni catalyst demonstrated that rGO was indeed a promising support to improve activity, enantioselectivity and durability of catalysts, and the prepared catalysts were promising reusable heterogeneous catalysts for asym. hydrogenation.

The article 《Reduced graphene oxide supported chiral Ni particles as magnetically reusable and enantioselective catalyst for asymmetric hydrogenation》 also mentions many details about this compound(53562-86-0)Safety of (S)-Methyl 3-hydroxybutanoate, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Cationic BINAP-Ru(II) Halide Complexes: Highly Efficient Catalysts for Stereoselective Asymmetric Hydrogenation of α- and β-Functionalized Ketones. Author is Mashima, Kazushi; Kusano, Koh-hei; Sato, Naomasa; Matsumura, Yoh-ichi; Nozaki, Kyoko; Kumobayashi, Hidenori; Sayo, Noboru; Hori, Yoji; Ishizaki, Takero.

Cationic ruthenium-BINAP complexes of the formula [RuX[(S)-BINAP](arene)]Y, where X = Cl, Br, I; Y = Cl, Br, I, BF4, B(C6H5)4; arene = benzene, p-cymene, Et benzoate, and their enantiomers have been prepared by the reaction of arene-ruthenium halide complexes with (S)-BINAP or (R)-BINAP [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]. Structures of the complexes were established by spectroscopy, conductivity, and a single-crystal x-ray anal. BINAP derivatives with various substituents at the para and meta positions of four Ph rings on phosphorus atoms and their cationic Ru(II) complexes have also been synthesized. These BINAP-Ru(II) complexes have been used as catalysts for the asym. hydrogenation of various unsaturated organic compounds such as α- and β-keto esters, allylic alcs., and α,β-unsaturated carboxylic acids in excellent diastereo- and/or enantioselectivities. Catalytic activities and stereoselectivities depend highly on reaction conditions such as solvent, temperature, and additives. Variation of halogen ligands bound to ruthenium atom and substituents on four Ph rings of BINAP also have exerted remarkable effects on the efficiency of the catalysis. Asym. hydrogenation of methyl(±)-2-(benzamidomethyl)-3-oxobutanoate catalyzed by the species derived from [RuI2(p-cymene)]2 and 3,5-(Me3C)2-BINAP afforded the corresponding syn-(2S,3R)-I in 98% de and 99% ee.

The article 《Cationic BINAP-Ru(II) Halide Complexes: Highly Efficient Catalysts for Stereoselective Asymmetric Hydrogenation of α- and β-Functionalized Ketones》 also mentions many details about this compound(53636-17-2)Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wang, Shi; Li, Yi Zhi; Zuo, Jing Lin; Li, Cheng Hui; You, Xiao Zeng published an article about the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3,SMILESS:[BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+] ).Safety of Potassiumtris(1-pyrazolyl)borohydride. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:18583-60-3) through the article.

The title compound crystallizes in trigonal space group R3̅, with a 22.676(2), c 13.5195(18) Å; the asym. unit comprises 1/2 of an [Fe(Tp)2]+ cation (where Tp = hydrotris(1-pyrazolyl)borato), with its Fe atom on a crystallog. inversion center, and 1/6 of an [Fe(NCS)6]3- anion, on a site of 3̅ symmetry. The anions and cations are stacked into a three-dimensional supramol. aggregate via two distinct types of weak C-H···π interactions.

The article 《Tris{bis[hydrotris(1-pyrazolyl)borato-κ3N2,N2′,N2”]iron(III)} hexaisothiocyanatoferrate(III)》 also mentions many details about this compound(18583-60-3)Safety of Potassiumtris(1-pyrazolyl)borohydride, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Inorganic Syntheses called Poly(1-pyrazolyl)borates, their transition-metal complexes, and pyrazaboles, Author is Trofimenko, Swiatoslaw, which mentions a compound: 18583-60-3, SMILESS is [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+], Molecular C9H10BKN6, SDS of cas: 18583-60-3.

K dihydrobis(1-pyrazolyl)borate (I) was prepared by heating KBH4 and pyrazole at 90° and then 125° until 50 l. of H has evolved. I is a crystalline solid, m.p. 171-2°, highly soluble in H2O and polar solvents. K hydrotris(1-pyrazolyl)borate (II) was prepared by following the procedure for the preparation of I until ∼35 l. H is evolved and then raising the temperature gradually to ∼190° until a total of 75 l. H is evolved. II is a white crystalline solid, m.p. 185-90°, and is very soluble in H2O, alcs. and polar organic solvents. K tetrakis(1-pyrazolyl)borate (III) was prepared by heating KBH4 and pyrazole until 100 l. H has evolved. III is a white solid, m.p. 253-4°, and is soluble in DMF and Me2SO but less soluble in H2O and alcs. Bis[dihydrobis(1-pyrazolyl)borato]nickel(II) (IV) was prepared by adding Ni(OAc)2 to a solution of I in H2O. IV forms well-shaped orange crystals, m.p. 181-2°, and is soluble in CH2Cl2, CHCl3, and aromatic hydrocarbons. Bis-[hydrotris(1-pyrazolyl)borato]cobalt(II) (V) was prepared by adding Co(OAc)2 to a solution of II in H2O. V is soluble in CH2Cl2, CHCl3, and aromatic hydrocarbons. Bis[tetrakis(1-pyrazolyl)borato]-manganese(II) (VI) was prepared by adding MnSO4 to a solution of III in DMF. VI is a crystalline white solid, m.p. 342-3°, sublimes at 280°C/1 mm, and is soluble in CH2Cl2, hot aromatic hydrocarbons, and dilute aqueous mineral acids. Pyrazabole (VII) and substituted pyrazaboles were prepared by the reaction of boranes and amine borane (Me3N.BH3) complexes with pyrazoles and substituted pyrazoles, resp. VII is a white crystalline solid, m.p. 80-1°, and is soluble in most organic solvents, less soluble in alcs. and insoluble in H2O. Addnl. examples are given for the preparation of substituted pyrazaboles.

The article 《Poly(1-pyrazolyl)borates, their transition-metal complexes, and pyrazaboles》 also mentions many details about this compound(18583-60-3)SDS of cas: 18583-60-3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Quality Control of 6-Acetylbenzo[d]oxazol-2(3H)-one. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Pharmacomodulation of the benzoxazolinone model by aryl-piperazine structure. Author is Bermann, Marie Christine; Bonte, Jean Paul; Lesieur-Demarquilly, Isabelle; Debaert, Michel; Lesieur, Daniel; Leinot, Michel; Benoit, Joseph; Labrid, Claude.

N-(Piperazinoalkyl)benzoxazolinones I (R = H, CF3, OMe, F, Me; n = 1, 2, 3; R1 = H, PhCO, 2-ClC6H4CO, MeCO, EtCO) were prepared from benzoxazolinones II; I have analgesic activity and are useful as psychotropics (no data). Thus, II (R1 = H) was heated with HCHO and 1-phenylpiperazine to give I (R = R1 = H, n = 1). I (n = 2, 3) were prepared from II and 1-(chloroalkyl)-4-phenylpiperazines.

The article 《Pharmacomodulation of the benzoxazolinone model by aryl-piperazine structure》 also mentions many details about this compound(54903-09-2)Quality Control of 6-Acetylbenzo[d]oxazol-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Product Details of 53562-86-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Synthesis of 1,1′-bis(phosphetano)ferrocenes, a new class of chiral ligands for asymmetric catalysis. Author is Marinetti, Angela; Labrue, Francis; Genet, Jean-Pierre.

The C2-sym., chiral 1,1′-bis(phosphetano)ferrocenes I (R = Me, CHMe2) were prepared from the cyclic sulfates of optically pure 1,3-diols. They were successfully tested in the Rh-catalyzed hydrogenation of unsaturated substrates. E.g., hydrogenation of H2C:C(CO2Me)CH2CO2Me in MeOH in presence of a rhodium catalyst formed in situ from (COD)2RhOTf and I (R = Me) gave 100% conversion to (R)-MeCH(CO2Me)CH2CO2Me in 91% ee.

The article 《Synthesis of 1,1′-bis(phosphetano)ferrocenes, a new class of chiral ligands for asymmetric catalysis》 also mentions many details about this compound(53562-86-0)Product Details of 53562-86-0, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics