Synthetic Route of C8H20Cl2N2O2SOn November 18, 2011 ,《Application of PAT tools for the safe and reliable production of a dihydro-1H-imidazole》 appeared in Organic Process Research & Development. The author of the article were Barrios Sosa, Ana C.; Conway, Ryan; Williamson, R. Thomas; Suchy, James P.; Edwards, William; Cleary, Thomas. The article conveys some information:
The application of two Process Anal. Technol. (PAT) tools was studied and implemented for the safe and reliable synthesis of an advanced intermediate (4S,5R-7) (I) of a member of the dihydro-1H-imidazole class of compounds Real time data were generated using ReactIR to track the complete breakdown of phosgene precursors to phosgene and confirm the absence of these hazardous materials prior to batch transfer operations. In addition, the chiral resolution by crystallization of rac7 was monitored by a Lasentec FBRM probe-based system. Implementation of the latter helped to track the crystallization process to minimize the risk of cocrystn. of undesired isomer 4R,5S-7. In addition to this study using 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride, there are many other studies that have used 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride(cas: 939983-66-1Synthetic Route of C8H20Cl2N2O2S) was used in this study.
1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride(cas: 939983-66-1) is a member of sulfones.The sulfones, like the sulfonamides, are structural analogs of para-aminobenzoic acid that interfere with folic acid metabolism by acting as competitive inhibitors of dihydropteroate synthetase. All sulfones of clinical value are derivatives of dapsone, the most widely used member of this class.Synthetic Route of C8H20Cl2N2O2S
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics