Category: piperazinesOn May 1, 2010 ,《Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Sandanayaka, Vincent; Mamat, Bjorn; Bhagat, Nikhil; Bedell, Louis; Halldorsdottir, Gudrun; Sigthorsdottir, Heida; Andresson, Torkell; Kiselyov, Alex; Gurney, Mark; Singh, Jasbir. The article conveys some information:
Novel piperidine and piperazine derivatives have been designed and tested as inhibitors of LTA4 hydrolase (LTA4H). Most potent compounds showed good potency in both enzymic and functional human whole blood assay. Crystallog. studies further confirmed observed structure-activity relationship and LTA4H binding mode for analogs from the piperidine series. In addition to this study using (4-Benzylpiperazin-2-yl)methanol, there are many other studies that have used (4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1Category: piperazines) was used in this study.
(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics