Benjahad, Abdellah; Benhaddou, Rachida; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; Piekarski, Salomon; Bosgiraud, Claudine; Delebassee, Sylvie published the artcile< Synthesis and antiretroviral evaluation of 3-alkyl-2-piperazinone nucleoside analogs>, Safety of 3,3-Dimethylpiperazin-2-one, the main research area is nucleoside analog synthesis antiretroviral; hydroxypropylpiperazinone glycosidation ribofuranose.
Glycosidation of 3-alkyl N4-(3-hydroxypropyl)-2-piperazinones by protected 1-O-acetyl ribofuranoses produces nucleoside analogs, e.g. I [R = R1 = H, Me; R = (CH2)9Me, R1 = H], in which the base is separated from the sugar by a hydrocarbon spacer arm. The preliminary in vitro test results against retro-viruses seem promising for compounds bearing a long alkyl chain.
Tetrahedron Letters published new progress about Antiviral agents. 22476-74-0 belongs to class piperazines, and the molecular formula is C6H12N2O, Safety of 3,3-Dimethylpiperazin-2-one.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics