Hieke, Martina; Roedl, Carmen B.; Wisniewska, Joanna M.; Buscato, Estella; Stark, Holger; Schubert-Zsilavecz, Manfred; Steinhilber, Dieter; Hofmann, Bettina; Proschak, Ewgenij published the artcile< SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase>, Synthetic Route of 197638-83-8, the main research area is imidazopyridinamine cyclohexyl morpholinophenyl preparation lipoxygenase inhibitor.
A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. The structure-activity relationships of this compound class was investigated. N-Cyclohexyl-6-methyl-2-(4-morpholinophenyl)imidazo[1,2-a]pyridine-3-amine was identified as a potent 5-LO inhibitor [IC50 = 0.16 μM (intact cells) and 0.1 μM (cell-free)], which may possess potential as an effective lead compound intervening with inflammatory diseases and certain types of cancer.
Bioorganic & Medicinal Chemistry Letters published new progress about 197638-83-8. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Synthetic Route of 197638-83-8.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics