Mondal, Milon; Unver, M. Yagiz; Pal, Asish; Bakker, Matthijs; Berrier, Stephan P.; Hirsch, Anna K. H. published the artcile< Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and -Optimization of Inhibitors of the Aspartic Protease Endothiapepsin>, Application of C16H22N2O3, the main research area is triazole protein templated click chem aspartic protease endothiapepsin inhibitor; click chemistry; drug design; enzymes; inhibitors; liquid chromatography.
There is an urgent need for the development of efficient methodologies that accelerate drug discovery. The authors demonstrate that the strategic combination of fragment linking/optimization and protein-templated click chem. is an efficient and powerful method that accelerates the hit-identification process for the aspartic protease endothiapepsin. The best binder, which inhibits endothiapepsin with an IC50 value of 43 μM, represents the first example of triazole-based inhibitors of endothiapepsin. The authors’ strategy could find application on a whole range of drug targets.
Chemistry – A European Journal published new progress about 1,3-Dipolar cycloaddition reaction. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Application of C16H22N2O3.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics