In 2019,Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry included an article by Manouchehrizadeh, Elham; Mostoufi, Azar; Tahanpesar, Elham; Fereidoonnezhad, Masood. COA of Formula: C5H12N2. The article was titled 《Design, synthesis, molecular docking and cytotoxic activity evaluations of novel piperidine and piperazine derivatives of dichloroacetate as potential anticancer agents》. The information in the text is summarized as follows:
A series of novel dichloro(piperidinyl/piperazinyl)-ethanone derivatives I [X = CH2, NH, NPh, etc.] of dichloroacetate was designed and subjected to mol. docking studies. Based on the docking results, compounds with the lowest binding energy and better interaction with PDKs isoenzymes were selected and synthesized. The cytotoxic activity of the synthesized compounds was evaluated against HT-29 and MCF7 human cancer cell lines. These compounds showed moderate potencies with much higher anticancer activity than DCA. The most active of the series, I [X = NH], showed IC50 value of 7.79μM against HT-29 cell line. In the experimental materials used by the author, we found 1-Methylpiperazine(cas: 109-01-3COA of Formula: C5H12N2)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..COA of Formula: C5H12N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics