Chopin, Nicolas; Yanai, Hikaru; Iikawa, Shinya; Pilet, Guillaume; Bouillon, Jean-Philippe; Medebielle, Maurice published the artcile< A Rapid Entry to Diverse γ-Ylidenetetronate Derivatives through Regioselective -Bromination of Tetronic Acid Derived γ-Lactones and Metal-Catalyzed Postfunctionalization>, Product Details of C16H22N2O3, the main research area is furanone tetronate preparation crystal mol structure.
The synthesis of a series of diverse Me and benzyl γ-ylidenetetronate derivatives was accomplished through the condensation of Me and benzyl tetronates with (hetero)aryl aldehydes in a new two-step or three-step aldolization/dehydration sequence. The bromination of Me and benzyl γ-ylidenetetronates occurred under mild conditions to provide the corresponding C-3-brominated γ-unsaturated lactones. Di- and tribrominated γ-lactones were prepared under slightly different conditions. Some brominated materials were employed in representative Stille, Suzuki-Miyaura , and Sonogashira cross-coupling reactions to yield functionalized Me and benzyl γ-ylidenetetronate derivatives Compounds that resulted from the Sonogashira cross-coupling reactions were desilylated and converted into 1,2,3-triazole derivatives through a copper(I)-catalyzed 1,3-dipolar cycloaddition reaction with benzyl azide. The synthesis of the target compounds was achieved by a reaction of 4-methoxy-2(5H)-furanone (Me tetronate), 4-(phenylmethoxy)-2(5H)-furanone (benzyl tetronate) with aldehydes. The title compounds thus formed included (5Z)-4-methoxy-5-(phenylmethylene)-2(5H)-furanone and related substances.
European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Product Details of C16H22N2O3.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics