Eddie, Sharon L.; Gregson, Aaron; Graham, Emma; Burton, Stephanie; Harrison, Timothy; Burden, Roberta; Scott, Christopher J.; Mullan, Paul B.; Williams, Rich published the artcile< Identification and SAR exploration of a novel series of Legumain inhibitors>, Name: 4-(4-Methyl-1-piperazinyl)phenylboronic Acid, the main research area is Legumain mall mol inhibitor SAR dipeptide; Legumain; SAR; Small molecule inhibitor.
This letter describes the development of a series of potent and selective small mol. Legumain inhibitors suitable as chem. probes for in vitro experiments Our previous research had identified a dipeptide inhibitor utilizing a semi-reversible cyano warhead that generated 2, a cell active inhibitor. This work explores an alternative P2-P3 linker and further SAR exploration of the P3 group which led to the identification of 16i, a highly potent inhibitor with excellent physiochem. properties.
Bioorganic & Medicinal Chemistry Letters published new progress about Dipeptides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (dipeptide Legumain inhibitors). 229009-40-9 belongs to class piperazines, and the molecular formula is C11H17BN2O2, Name: 4-(4-Methyl-1-piperazinyl)phenylboronic Acid.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics