Product Details of 70006-24-5On October 27, 2006 ,《Gram Scale Synthesis of the Glucuronide Metabolite of ABT-724》 was published in Journal of Organic Chemistry. The article was written by Engstrom, Kenneth M.; Daanen, Jerome F.; Wagaw, Seble; Stewart, Andrew O.. The article contains the following contents:
A gram scale synthesis of the glucuronide metabolite of ABT-724 is reported. Glycosidic coupling between a trichloroacetimidate glucuronyl donor and a Cbz-protected hydroxypyridylpiperazine glycosyl acceptor is the key step in the synthesis, since attempts to directly glucuronidate the aglycon, aglycon derivatives, and other truncated glycosyl acceptors were unsuccessful. The route was used to produce 2.1 g of metabolite in eight steps from 2-chloro-5-hydroxypyridine in 21% overall yield. In the part of experimental materials, we found many familiar compounds, such as Abt-724(cas: 70006-24-5Product Details of 70006-24-5)
Abt-724(cas: 70006-24-5) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.Product Details of 70006-24-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics