Faigle, Johann W.; Blattner, Hans; Glatt, Hansruedi; Kriemler, Hans Peter; Mory, Hans; Storni, Angelo; Winkler, Tammo; Oesch, Franz published their research in Helvetica Chimica Acta on August 12 ,1987. The article was titled 《Structures and mutagenic properties of products obtained by C-nitrosation of opipramol》.Application of 3445-00-9 The article contains the following contents:
Reaction of the tricyclic psychotropic drug opipramol (I) with an excess of HNO2 gave a product mixture mutagenic to Salmonella typhimurium. The main product is a tetracyclic furoxan II (yield ca. 80%), resulting from nitrosation at C(10) and C(11) of I. II is not mutagenic. The essential mutagen is a nitroarene III, formed by contraction of the central ring of I and nitrosation at C(2). The yield of III is extremely low (<0.1%). Mutagenic nitroarenes have previously not been encountered as products from the interaction of drugs with nitrite. The results came from multiple reactions, including the reaction of 2-(4-(3-Chloropropyl)piperazin-1-yl)ethanol dihydrochloride(cas: 3445-00-9Application of 3445-00-9)
2-(4-(3-Chloropropyl)piperazin-1-yl)ethanol dihydrochloride(cas: 3445-00-9) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.Application of 3445-00-9
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics